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Pathology

Image: Electron micrograph of human papillomavirus (HPV) (Photo courtesy of the [US] National Institutes of Health).

DNA-Based Test Predicts Likelihood of HPV-Linked Oral Cancer Recurrence

A recent paper described using a real-time quantitative polymerase chain reaction to detect human papillomavirus DNA in saliva and blood for the diagnosis of oropharyngeal squamous cell carcinoma and to predict likelihood of recurrence of the disease after treatment.   More...
13 Aug 2014

Genomic Assay Predicts Biochemical Failure and Risk of Metastasis in Prostate Cancer Patients After Surgery and Radiation Therapy

An advanced genomic test has been used to predict the course of prostate cancer in patients following surgery and radiation treatment.  More...
13 Aug 2014
Image: The single cell gel electrophoresis assay or “comet” test (Photo courtesy of the Belgian BioElectroMagnetics Group).

Sensitivity of White Blood Cell DNA to Damage from UV Light Distinguishes Cancer Patients from Healthy Individuals

A simple test that measures the extent of damage to white blood cell DNA caused by exposure to ultraviolet light has the potential to detect individuals with cancer before the appearance of any detectable symptoms.  More...
13 Aug 2014
Image: The photomicrograph shows the appearance of a low grade carcinoma of the prostate that can be difficult to recognize as malignancy, particularly in small needle biopsies (Photo courtesy of the University of Washington).

Accurate Epigenetic Test Eliminates Superfluous Biopsies for Prostate Cancer

Two independent trials have now validated the performance of an epigenetic test that could provide physicians with a better tool to help eliminate unnecessary repeat prostate biopsies.  More...
06 Aug 2014

Mutation That Induces High Blood Pressure in Women Linked to Increased Heart Attack Risk

A mutation in women in the G-protein coupled estrogen receptor 30 gene generates a receptor with reduced activity that induces high blood pressure, the single biggest risk factor for heart attack and stroke.  More...
05 Aug 2014
Image: The Qubit 2.0 fluorometer (Photo courtesy of Invitrogen).

Innovative Methodology Translates Noncoding DNA in Colorectal Cancer

Although the genetic origins of cancers have been studied for a long time, scientists were not able to measure the role of noncoding regions of the genome until now.  More...
05 Aug 2014
Image: Histopathology of a child’s kidney showing one glomerulus (arrow) with matrix expansion and uniform thickening of the basement membrane. The tubules show mild atrophy and the interstitium contains patchy moderate infiltrates. The appearance is consistent with membranous nephropathy (Photo courtesy of Dr. S. K. Pradhan).

Genetic Test Predicts Therapeutic Response in Pediatric Kidney Disease

Genetic mutations in the kidney’s filtration barrier are frequently linked with a lack of response to immunosuppressive treatments among children with sporadic nephrotic syndrome.  More...
05 Aug 2014
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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