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Pathology

Image: Histopathology of a spinal cord from an infant with multiple joint contractures present at birth (Photo courtesy of Dimitri P. Agamanolis, MD).

Infant Stiff-Joint Syndromes Matched to Possible Genetic Origins

There are over 400 specific disorders that are, or can be, associated with multiple contractures in the newborn and a better understanding of disorders with contractures and their associated genetics is critical for accurate diagnosis and optimal treatment.  More...
25 May 2015

Panel of Bloodstream MicroRNAs Predicts Damage from Radiation Exposure

A panel of microRNAs that can be measured in blood samples is able to predict the extent of long-term radiation injury and likelihood of survival following exposure to high doses of radiation.  More...
25 May 2015
Image: Left: Quantitative phase image of an unstained prostatectomy sample from a patient who had a biochemical recurrence of prostate cancer. Right: A zoomed-in region from the quantitative phase image showing a cancerous gland with debris in the lumen. The stroma, or supportive tissue environment, shows discontinuities in the fiber length and disorganization in the orientation of the fibers (Photo courtesy of the University of Illinois).

Pathologists Use Spatial Light Interference Microscopy to Predict Risk of Prostate Cancer Recurrence Prior to Biopsy or Surgery

A novel microscopy method that combines phase contrast microscopy with holography enables prediction of the likelihood of prostate cancer recurrence prior to biopsy or surgery.  More...
24 May 2015
Image: A user calibrates a newly developed portable polarimetric fiber stress sensor device while studying tumors by measuring Young’s modulus—an elasticity-related property recently linked to cancerous tumor aggressiveness (Photo courtesy of Kelvin Kuo, University of Southern California).

Portable Device Could Test for Physical Property of Tumor Aggressiveness

A new polarimetric fiber stress sensor device has been developed for visco-elastic and biomimetic material analysis, and, as part of the emerging field of physical oncology, is being tested for measuring a tumor’s Young’s modulus—an elasticity-related measure recently linked to cancerous tumor aggressiveness.  More...
24 May 2015
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Molecular Urine Test Identifies Lung Carcinoma Mutations

The monitoring of circulating tumor DNA is a promising technique that may provide clinicians with a faster, cheaper and less invasive way to evaluate the clinical status and response to therapy of cancer patients.   More...
20 May 2015
Image: The measuring channel that forms the key component of the PoCyton cytometer is visible on the right-hand side of the image (Photo courtesy of Fraunhofer ICT-IMM).

Automatic Cytometer Tallies Tumor Cells in Blood

Flow cytometry has been used to count cancer cells for many years, but the large instruments are expensive and can only be operated by trained personnel.  More...
19 May 2015
Image: Histopathology of a Brenner tumor, a type of surface epithelial-stromal tumor, which may be benign or malignant, depending on whether the tumor cells invade the surrounding ovarian tissue (Photo courtesy of Nephron).

Ovarian Cancer Screening Technique Doubles Detection Rates

A risk algorithm using serial biomarker measurements doubles the number of screen-detected ovarian cancers compared to a single threshold rule.  More...
18 May 2015
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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