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Pathology

Image: The nCounter analysis system (Photo courtesy of NanoString Technologies).

Rare Inflammatory Disease Identified in Children

A rare, deadly inflammatory disease among young children, known as otulipenia has been discovered, and it is caused by the malfunction of OTULIN, a gene on chromosome 5 that regulates the development of new blood vessels and the mobilization of infection-fighting cells and proteins. More...
20 Sep 2016
Image: The NuQ Triage colorectal cancer screening test detects epigenetic changes to nucleosomes (DNA fragments) (Photo courtesy of VolitionRx).

Triage Colorectal Cancer Screening Test Should Reduce Colonoscopy Referral

The most frequently used first line screening test for colorectal cancer across Europe is the fecal immunochemical test (FIT) and patients with a positive score following FIT tests are then referred for colonoscopy. More...
20 Sep 2016
Image: The semi-quantitative Calprotectin 50 + 200 combo card test (Photo courtesy of CerTest Biotec).

Sensitive Clinical Marker Defined for Ulcerative Colitis Evolution

The two main subtypes of inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are characterized by episodes of inflammatory activity and remission and determination of disease activity remains challenging, with most clinical scores correlating poorly with the inflammatory state. More...
20 Sep 2016
Image: A positive case of lung tissue detected by IHC-staining for anaplastic lymphoma kinase (ALK) with Ventana ALK (D5F3) CDx assay (Photo courtesy of Ventana).

Combined Use of Assays Identifies Cancer Patient Response to Crizotinib

In screening of a large cohort for anaplastic lymphoma kinase (ALK) fusions through both fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) assays, researchers found many non-small cell lung cancer (NSCLC) patients who had negative and atypical FISH patterns accompanied with positive IHC results, who showed response to crizotinib treatment. More...
19 Sep 2016
Image: The cantilever on the left bears the recognition sequence for the target mutation. If this is present in the sample being tested, the corresponding segment of RNA binds to the cantilever, causing the latter to bend. This can be measured, providing clear evidence that the genetic change is present (Photo courtesy of the University of Basel, Department of Physics).

Microcantilever-Based Sensor Detects BRAF-Mutated Malignant Melanoma

A novel nanosenor comprising minute cantilevers labeled with malignant melanoma-derived RNA enabled identification of patients with the BRAFV600E mutated form of the disease in less than 24 hours. More...
19 Sep 2016
Image: The BMG OPTIMA FLUOstar plate reader (Photo courtesy of BMG LABTECH).

Early Parkinson's Diagnosis Moves Closer with New Protein Test

There is currently no definitive test for Parkinson's and the disease is normally diagnosed through assessment of the patient's medical history, a medical examination, and physical and neurological tests, but this can take years. More...
15 Sep 2016
Image: The BD LSRII flow cytometer (Photo courtesy of Becton Dickinson).

Circulating Immune Cells Act As Idiopathic Pulmonary Fibrosis Biomarkers

Patients with fibrotic lung diseases, such as idiopathic pulmonary fibrosis (IPF), show progressive worsening of lung function with increased shortness of breath and dry cough. More...
14 Sep 2016
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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