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Pathology

Image: Electron micrograph of a bladder cancer cell: clinical pathology tests outperform molecular subtyping in bladder cancer (Photo courtesy of Jim Stallard).

Standard Pathology Tests Outperform Molecular Subtyping in Bladder Cancer

 Evolving diagnostic approaches include compiling databanks on gene expression and mutations present in a cancer type to find patterns of gene expression that are then used to subtype tumors that "pathologically look similar" but are molecularly different. More...
02 Jan 2020
Image: The cancer screening platform was a  multitarget stool DNA test (MT-sDNA), that uses multiple biomarkers to ensure the highest levels of sensitivity (Photo courtesy of Exact Sciences Laboratory)

Stool DNA Test Helps Detect Precancerous Lesions

 Colorectal cancer (CRC) is the third most common cancer and is one of the leading causes of cancer-related mortality. Although CRC incidence is increasing, a decrease in mortality has been observed due to the implementation of CRC screening and improved therapies. More...
27 Dec 2019
Image: The BD FACSAria III fluorescent activated cell sorter used to enumerate circulating progenitor cells (Photo courtesy of Becton, Dickinson and Company.

Circulating Progenitor Cell Traffic Reflects Blood Vessel Repair

 Identifying patients with otherwise stable coronary artery disease (CAD) who are high-risk and would benefit from more intense or invasive interventions is currently a major theme in cardiology studies. More...
18 Dec 2019
Image: Histopathology of Wilms tumor or nephroblastoma which is a type of kidney cancer that is seen predominantly in children (Photo courtesy of Nephron).

Childhood Kidney Cancer Arises from Altered Normal Tissue

 While kidney cancer in children is rare, the most common type is Wilms tumor, which mostly affects children under the age of five. Most cases of Wilms tumor can be cured through surgery to remove the afflicted kidney in combination with chemotherapy and possibly radiotherapy. More...
16 Dec 2019
Image: Trypanosoma cruzi amastigotes in heart tissue from a patient with Chagas disease (Photo courtesy of the CDC)

Chronic Comorbidities Are Prevalent Among People with Chagas Disease

 Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. More...
12 Dec 2019
Image: Diazyme`s D-Dimer Assay is a highly sensitive liquid stable latex enhanced immunoturbidimetric test kit, designed to work on most open clinical chemistry analyzers to provide rapid results with reduced reagent cost (Photo courtesy of Diazyme Laboratories)

Pulmonary Embolism Diagnosed by Improved Interpretation of Blood Tests

 Pulmonary embolism is the sudden blockage of a major blood vessel (artery) in the lung, usually by a blood clot. In most cases, the clots are small and are not deadly, but they can damage the lung and if the clot is large and stops blood flow to the lung, it can be deadly. More...
10 Dec 2019
Image: Colored positron emission tomography (PET) scans of axial sections through a healthy brain (upper) and a schizophrenic brain (lower). Genetic architectures of schizophrenia in East Asian and European populations have been compared (Photo courtesy of WebMD)

Genetic Architectures of Schizophrenia Compared in Different Populations

 While the common genetic variants contributing to schizophrenia in East Asian individuals appear to broadly resemble those found in Europeans, polygenic risk scores (PRS) for the condition cannot necessarily be transferred from one population to the next. More...
05 Dec 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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