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Pathology

Image: Germline Risk Variants Found in Prostate Cancer Patients Using the Heredity Testing Kit (Photo courtesy of Invitae).

Germline Risk Variants Found in Prostate Cancer Patients

Studies done over the past five years or so have unearthed pathogenic germline variants in some 12% to 17% of men with prostate cancer, and such alterations can impact everything from the treatment options available to them, to the management strategies used for other members of the same family. More...
21 May 2020
Image: Schematic diagram of the Adenoma-Carcinoma Sequence; a non-invasive blood assay, FirstSightCRC, can detect early colorectal cancer (Photo courtesy of CellMax Life).

Non-Invasive Blood Assay Can Detect Early Colorectal Cancer

Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). In general, colon cancer begins when healthy cells in the colon develop changes (mutations) in their DNA and as the cells accumulate, they form a tumor. More...
21 May 2020
Image: A blood smear from a patient with microcytosis which may predict underlying cancer even in the presence of normal hemoglobin. Microcytic red blood cells measure 6 μm or less in diameter. The mean corpuscular volume is generally less than 80 fL (Photo courtesy of Sara Beth Fazio, MD).

Microcytosis Is a Risk Marker of Cancer in Primary Care

Microcytosis is a term used to describe red blood cells that are smaller than normal. Anemia is when there are low numbers of properly functioning red blood cells in the body. In microcytic anemia, the body has fewer red blood cells than normal and those red blood cells it does have are also too small. More...
20 May 2020
Image: Schematic diagram of Molecular Characterization Identifying Distinct Molecular Hallmarks of Renal Medullary Carcinoma (Photo courtesy of University of Texas MD Anderson Cancer Center).

Rare Kidney Cancer Marked by Molecular Features

Renal medullary carcinoma is a rare cancer of the kidney that predominantly afflicts young people of African descent who carry the sickle cell trait, sickle cell disease, or other sickle hemoglobinopathies that can cause sickling of the red blood cells. More...
19 May 2020
Image: Schematic diagram of circulating tumor DNA (ctDNA) which is found in serum and plasma fractions from blood. The mechanism of ctDNA release is unknown, though apoptosis, necrosis, and active secretion from tumor cells have been hypothesized. Once ctDNA is isolated, it can be sequenced for mutational analysis (Photo courtesy of Rachel June Wong).

Blood Test Shows Promise for Predicting Cancer

Early detection of most cancers is an elusive and daunting task; nevertheless, it has remained a top priority for the cancer research community. Detecting cancer early has manifold advantages: it can increase a patient’s chances of successful treatment, prolong their survival, and substantially improve their quality of life. More...
14 May 2020
Image: Clostridium septicum is a gram positive, spore forming, obligate anaerobic bacterium and increases the risk of colon cancer (Photo courtesy of Alchetron).

Bacterial Blood Infections Tied to Heightened Colon Cancer Risk

Colorectal cancer occurs in the colon or the rectum and it is the third most common type of cancer in the USA. Around 90% of cases occur in people aged 50 years or older. As well as age, risk factors include a family history of colorectal cancer, some genetic syndromes, obesity, and a lack of exercise, a diet low in fruit and vegetables, and inflammatory bowel disease. More...
12 May 2020
Image: Multicancer Blood Test Aids Screen for Cancer Guide Intervention (Photo courtesy of fotoquique/Depositphotos).

Multicancer Blood Test Aids Screen for Cancer Guide Intervention

As minimally invasive screening tests, liquid biopsies could help reduce cancer-specific morbidity and mortality through earlier detection. However, there is debate on how to effectively screen large populations for cancer, including individuals who do not have symptoms or history of the disease. More...
12 May 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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