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Immunology

Image: The 4 main components of the newly developed “lab-in-a-briefcase.” (1) Disposable multiple syringe aspirator (MSA) devices, each of which can perform 10 replicate ELISA tests on each of the 8 samples. (2) Customized microwell plates preloaded with reagents that interface with the MSA. (3) Portable USB-powered film scanner for colorimetric signal quantification. (4) Portable computer for real-time data analysis (Photo courtesy of Barbosa AI et al., 2015, and the journal Lab on a Chip.)

First Lab-in-a-Briefcase to Boost Global Early Diagnosis of Cancer

To help boost early cancer detection rates worldwide, scientists have developed an all-in-one portable mini-laboratory for point-of-care cancer screening, rapid detection, and monitoring. The prototype successfully tested for prostate cancer, and can operate at even at high temperatures often found in remote areas without air-conditioned clinics.  More...
18 Nov 2015
Image: The suPARnostic kit measures soluble urokinase-type plasminogen activator receptor, a biomarker for kidney disease, by lateral cytometry test in plasma. The reading is performed in a small colorimeter (Photo courtesy of ViroGates).

Early Warning Biomarker Found for Chronic Kidney Disease

A simple blood test for a specific protein can predict a person's chances of developing chronic kidney disease five years before symptoms emerge, thus doing for kidney disease what cholesterol has done for cardiovascular disease.   More...
18 Nov 2015
Image: Colored scanning electron micrograph of T-lymphocytes (pink) that recognize antigens on a tumor cell (yellow) through T-cell receptors (Photo courtesy of Steve Gschmeissner).

Breakthrough Technology Characterizes Immune Response

Assays enabling the identification and enumeration of antigen-specific T cells are critical tools in characterizing immune responses and harnessing T cell function for treatment of numerous diseases including cancer.  More...
16 Nov 2015
Image: Transmission electron micrograph of numerous Chikungunya virus particles which are composed of a central dense core surrounded by a viral envelope ((Photo courtesy of Cynthia Goldsmith).

Simple Affordable Diagnostic Kit Developed for Chikungunya

Chikungunya, a mosquito-borne illness that while not often deadly causes severe, incapacitating and often chronic joint pain, is spreading globally and it can be difficult to diagnose and most tests available now are expensive and challenging to develop.  More...
11 Nov 2015
Image: Tissue smear from a patient infected with Leishmania infantum showing numerous protozoan bodies phagocytized by macrophages (Photo courtesy of Dr. Yutaka Tsutsumi).

Cytokine Release Assays Tests for Leishmaniasis in Transplant Recipients

Cytokine release assays have been used to determine the prevalence of Leishmania infantum infection in solid organ transplant recipients living in an area where the organism is endemic following an outbreak.  More...
09 Nov 2015
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Surface Marker Allows New Diagnostic Approaches for Sarcoidosis

A new strategy has been developed to determine monocyte subsets involved in diseases that could help facilitate the diagnosis of sarcoidosis and may improve respective patient management.  More...
08 Nov 2015
Image: The “PD-L1 IHC 28-8 pharmDx” immunohistochemical assay identifies PD-L1 expression levels on the surface of non-small-cell lung cancer (NSCLC) tumor cells. It is the only diagnostic assay FDA-approved to assess survival benefit associated with OPDIVO (nivolumab) therapy for patients with non-squamous NSCLC (Photo courtesy of Dako Denmark).

FDA Approves First of its Kind Companion Dx for Lung Cancer Patients

The US Food and Drug Administration have approved the first complementary diagnostic test to support use of OPDIVO for non-squamous non-small-cell lung cancer therapy.  More...
02 Nov 2015
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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