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Hematology

Image: The BD FACSAria III sorter is equipped with five lasers, 17 fluorescence channels and two channels for Forward Scatter and Side Scatter (Photo courtesy of BD Biosciences)

Genome Sequencing Identifies Myeloma Precursor Disease with Progression Risk

Multiple myeloma (MM) is the second most common hematological malignancy and is consistently preceded by the asymptomatic expansion of clonal plasma cells, termed either monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). More...
08 Apr 2021
Image: The ERMA PCE-210N fully automatic cell counter (Photo courtesy of ERMA)

Flow-Cytometric Expression of Endoglin Assessed in B-Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a malignant disorder representing clonal expansion and arrest of maturation of lymphoid progenitor cells in the bone marrow, blood, and extramedullary sites. The incidence of ALL generally follows a bimodal distribution, with its first peak occurring in childhood and the second around the age of 50. More...
01 Apr 2021
Image: Autoreactive B Cells seen in Systemic Lupus Erythematosus (Photo courtesy of Sebastian Kaulitzki)

Lupus Genetic Risk Variant Allelic Enhancer Activity Discovered

Systemic lupus erythematosus (SLE) affects about 300,000 people in the USA, the majority of whom are women. Previous studies have implicated both genetic and environmental contributors to the condition. While nearly 100 genetic loci have been associated with lupus, it is also closely tied to previous infection with Epstein-Barr virus. More...
31 Mar 2021
Image: The NovaSeq 6000 sequencing instrument (Photo courtesy of Illumina)

Genome Sequencing More Informative than Cytogenetic Analysis in Myeloid Cancers

Genetic profiling is a routine component of the diagnostic workup for an increasing number of cancers and is used to predict clinical outcomes and responses to targeted therapies. Genomic analysis is essential for risk stratification in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). More...
24 Mar 2021
Image: Bone marrow smear showing vacuoles in myeloid cells in a patient with VEXAS (Photo courtesy of Katherine Calvo, MD, PhD, and Marcela Ferrada, MD)

Genetic Mutations Identified for Rare VEXAS Syndrome

VEXAS syndrome is a serious inflammatory condition which develops in men over 50, causing them to become very sick and fatigued, and can be fatal. It was originally thought to be rare, but a new study has identified genetic mutations which indicate that the disease is actually much more common. More...
23 Mar 2021
Image: The HYDRASYS 2 Electrophoresis Automated System (Photo courtesy of Sebia).

Paraproteins Identification Methods Compared for Monoclonal Gammopathies

Monoclonal gammopathy, also known as paraproteinemia, is the presence of excessive amounts of myeloma protein or monoclonal gamma globulin in the blood. It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma. More...
18 Mar 2021
Image: Model of clonal hematopoiesis in normal and inflammatory conditions. In a normal person, hematopoietic stem cells (HSCs) will differentiate and self-renew over the course of a lifetime to replenish the blood system. HSCs will acquire somatic mutations as a result of proliferative stress (Photo courtesy of University of California Irvine).

Clonal Hematopoiesis and Recurrent Mutations Identified in Blood Cancers

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by detectable hematopoietic-associated gene mutations in a person without evidence of hematologic malignancy. Somatic mutations at hotspots (genetic loci observed to be frequently mutated across cancer patients) often drive or contribute to cancer pathogenesis. More...
16 Mar 2021
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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