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Pathology

Image: A histopathology of high-grade invasive ductal carcinoma of the breast (not otherwise specified, grade 3). This is an example of a triple-negative breast cancer, basal-like carcinoma (Photo courtesy of Lee Moffitt Cancer Center).

Triple-Negative Breast Cancer Classified from Whole-Genome Sequencing

A diagnosis of triple negative breast cancer means that the three most common types of receptors known to fuel most breast cancer growth–estrogen, progesterone and the HER-2/neu gene are not present in the cancer tumor. More...
16 Oct 2019
Image: Scanning electron photomicrograph (SEM) of breast cancer cells. Unselected, high-risk multigene testing for all patients with breast cancer is extremely cost-effective (Photo courtesy of Marie Thibault).

Multigene Testing for Breast Cancer Patients Proves Cost-Effective

Health systems in the UK and USA could cost-effectively screen all women with breast cancer for risky germline changes in a handful of breast or ovarian cancer genes, according to a new economic modeling analysis, identifying at-risk individuals who could benefit from additional imaging tests and cancer-reducing interventions. More...
16 Oct 2019
Image: A new blood test has been developed capable of detecting multiple cancer types. The new test looks for DNA, which cancer cells shed into the bloodstream when they die (Photo courtesy of weeksnews).

New Blood Test Capable of Detecting Multiple Cancer Types

A new blood test in development has shown ability to screen for numerous types of cancer with a high degree of accuracy, a trial of the test shows. In study, test proved able to detect and localize more than 20 types of cancer with a high degree of accuracy. More...
16 Oct 2019
Image: The NovoCyte flow cytometer (Photo courtesy of ACEA Bio).

Blood Monocyte Functions Altered in Parkinson's Disease

Parkinson's disease is characterized by the slow degeneration of the neurons in brain due to the abnormal accumulation of a protein called alpha-synuclein. This leads to the patients shaking and then to the slow, stiff movements which many people associate with the disease. More...
15 Oct 2019
Image: The Gen-S hematology analyzer (Photo courtesy of Beckman Coulter).

Hematological Parameters Detect Patients with Acute VTE

Venous thromboembolism (VTE) encompasses deep venous thrombosis (DVT) and pulmonary embolism (PE). VTE causes cardiovascular death and disability and the risk of PE‐associated mortality and morbidity extends far beyond the acute phase of the disease. More...
08 Oct 2019
Image: The use of RNA-seq as a decentralized methodology at the core of the MammaPrint and BluePrint microarray-based diagnostic technology (Photo courtesy of Agendia).

Targeted RNA Sequencing Technology Diagnoses Breast Cancer

In recent years, RNA-sequencing (RNA-seq) technology has become the standard for transcriptome analysis because of its flexibility, sensitivity, and accuracy in measuring gene expression. RNA-seq is a technology in which cDNA is derived from RNA, followed by library construction and massively parallel deep sequencing. More...
01 Oct 2019
Image: Examples of erythrocyte sedimentation rates (ESR) from normal to pathological conditions. This test indirectly measures the degree of inflammation present in the body (Photo courtesy of The Netherland Association for Hematology).

Biomarker in Adolescence Linked to Early Mortality

Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. More...
27 Sep 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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