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Pathology

Image: Immunohistological micrograph showing a programmed death-ligand 1 (PD-L1) positive non-small cell lung carcinoma (Photo courtesy of Creative Commons BY-SA 4.0/Wikimedia).

Blood Test Predicts Response to Immunotherapy in Metastatic NSCLC

 Non-small cell lung cancer (NSCLC) patients with higher measures of tumor mutations that show up in a blood test generally have a better clinical response to PD-1-based immunotherapy treatments than patients with a lower measure of mutations. More...
10 Mar 2020
Image: Electronic Nose Device Can Detect Esophageal Cancer Precursor (Photo courtesy of Radboud University Medical Center).

Esophageal Cancer Precursor Detected by Electronic Nose Device

 Barrett's esophagus is a condition in which the lining of the esophagus changes, becoming more like the lining of the small intestine rather than the esophagus. This occurs in the area where the esophagus is joined to the stomach. More...
10 Mar 2020
Image: The ClearCell FX1 novel platform for detect circulating tumor DNA from blood samples (Photo courtesy of Explorea s.r.o.).

Heterogeneous Populations of Melanoma Circulating Tumor Cells Detected

 Circulating tumor cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. More...
02 Mar 2020
Image: Microscopic examination of bronchoalveolar lavage fluid revealing the presence of Strongyloides stercoralis larvae in hemorrhagic background (Photo courtesy Kyung-Nyeo Jeon, MD, PhD).

Severe Strongyloidiasis Infection Reported in Kidney Transplant Recipients

 Strongyloides stercoralis is a soil-transmitted human pathogenic parasitic roundworm causing the disease strongyloidiasis. It is found in tropical and subtropical regions worldwide. Many people infected are asymptomatic at first. Symptoms include dermatitis: swelling, itching, larva currens, and mild hemorrhage at the site where the skin has been penetrated. More...
25 Feb 2020
Image: Proteogenomic Characterization of Endometrial Carcinoma (Photo courtesy of the Clinical Proteomic Tumor Analysis Consortium).

Proteogenomic Characterization of Endometrial Carcinoma Analyzed

 Endometrial cancer is a cancer that arises from the endometrium which is the lining of the uterus or womb. It is the result of the abnormal growth of cells that have the ability to invade or spread to other parts of the body. More...
24 Feb 2020
Image: This side-by-side comparison of a breast tissue biopsy demonstrates some of the infrared-optical hybrid microscope’s capabilities. On the left, a tissue sample dyed by traditional methods. Center, a computed stain created from infrared-optical hybrid imaging. Right, tissue types identified with infrared data. The pink in this image signifies malignant cancer (Photo courtesy of Rohit Bhargava, PhD).

All-Digital Histopathology Attained by Infrared-Optical Hybrid Microscopy

 The gold standard of tissue pathology is to add dyes or stains so that pathologists can see the shapes and patterns of the cells under a microscope. However, it can be difficult to distinguish cancer from healthy tissue or to pinpoint the boundaries of a tumor, and in many cases diagnosis is subjective. More...
24 Feb 2020
Image: Normal electrocardiogram (ECG) and an ECG showing QT interval prolongation (long QT syndrome). The P wave represents atrial depolarization; the QRS complex, ventricular depolarization; and the T wave, ventricular repolarization. The QT interval is measured from the beginning of the QRS complex to the return of the T wave to the isoelectric line (Photo courtesy of Mayo Clinic).

Several Genes Linked to Long QT Syndrome Reappraised

 Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia. Over the last 25 years, multiple genes have been reported to cause this condition and are routinely tested in patients. More...
20 Feb 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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