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Clinical Chemistry

Image: High magnification micrograph of a renal oncocytoma. The tumor cells (left of the image) are arranged in nests, have slightly enlarged nuclei and have a more eosinophilic (darker pink) cytoplasm than the normal kidney - renal tubules (right of image) (Photo courtesy of Nephron).

Retina Protein Antibodies Used As Kidney Cancer Marker

Renal cell carcinoma (RCC) is the second-most common uronephrological cancer. In the absence of specific symptoms, early diagnosis of RCC is challenging. Monitoring of the aberrant expression of tumor-associated antigens (TAAs) and related autoantibody response is considered as a novel approach of RCC diagnostics. More...
28 Jan 2019
Image: Testing blood glucose regularly allows for glycemic control strategy (Photo courtesy of the American Academy of Family Physicians).

Biochemical Hypoglycemia Associated with Risk of Hypoglycemia

To optimize diabetes management, it is essential to have assessments of both hyperglycemia and hypoglycemia. Glycated hemoglobin (HbA1c) is primarily a measure of hyperglycemia, but it provides no indication of the frequency or severity of hypoglycemia. More...
24 Jan 2019
Image: The Calprolab enzyme-linked immunosorbent assay (ELISA ALP) test kit for calprotectin estimation (Photo courtesy of Calpro).

Calprotectin Independently Predicts Relapse in Treated RA

Calprotectin is a biomarker of disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and predicts relapse in juvenile idiopathic arthritis. Higher drug trough serum levels are associated with a good response in patients treated with tumor necrosis factor inhibitors (TNFi). More...
14 Jan 2019
Image: The AU 5800 automatic analyzer (Photo courtesy of Beckman Coulter).

Fructosamine Reference Range Established for Brazil

Traditional markers used in diabetes diagnosis and monitoring include fasting plasma glucose (FPG), two-hour plasma glucose (2-hPG) measured during the oral glucose tolerance test (OGTT), and glycated hemoglobin (HbA1c) levels. More...
14 Jan 2019
Image: The BN II Nephelometer System is an easy-to-use, reliable nephelometric analyzer that offers a broad range of protein assays (Photo courtesy of Siemens Healthcare).

Urinary Biomarkers Associated with Kidney Disease Risk Factors

The improved life expectancy among treated human immunodeficiency virus (HIV)-positive patients has been tempered by the excess burden of age-related non-infectious co-morbidities, including chronic kidney disease (CKD). More...
14 Jan 2019
Image: The FLUOstar Omega is a multi-mode microplate reader and has six detection modes (Photo courtesy of BMG LabTech).

Test Detects Protein Associated with Alzheimer’s and CTE

An ultrasensitive test has been developed that detects a corrupted protein associated with Alzheimer’s disease and chronic traumatic encephalopathy (CTE). This advance could lead to early diagnosis of these conditions and how they originate. More...
09 Jan 2019
Image: The Hitachi 7600 chemistry analyzer (Photo courtesy of Hitachi).

Bilirubin Improves Risk Prediction of Cardiovascular Death

Diabetes is one of the most prevalent disorders worldwide and cardiovascular (CV) disease is the leading cause of mortality and morbidity in diabetic patients. Therefore, improvements in risk prevention and adequate treatment are needed in these high-risk subjects. More...
07 Jan 2019
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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